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Shirley Wen


Founder/CEO


● 10+ years of interdisciplinary product and managing experience, transforming traditional businesses with frontier digital technologies

● Ex hegdefund portfolio manager, focused on healthcare, TMT, and consumer

● MSc Accounting & Finance, The London School of Economics


中文|English

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Douglas McCloskey, Ph.D.


Co-founder/Chief Scientist


● Systems biologist experienced in developing automated Big Omics Data generation and analysis workflows


● Group leader, Center for Biosustainability (CfB) at the Technical University of Denmark (DTU)


● Ph.D., Bioengineering, University of California, San Diego in the Bernhard Ø. Palsson lab


● Recipient of the Siebel Scholar – awarded annually for academic excellence and demonstrated leadership to 93 top students from the worlds leading graduate schools


● Publication H-index of 21




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Dimitris Christodoulou, Ph.D.


Co-founder/Chief Strategy Officer


● Strategist & computational biologist with experience in data analytics, multi-omics integration & simulation

● Ex-Senior Consultant at Deloitte Consulting (Zurich), led the design and implementation of business and technology strategies as well as data solutions for global MNCs

● Visiting Scholar in Systems Biology, Harvard Medical School

● Ph.D. & Post-Doc, Computational Biology, ETH Zurich

● Published multiple top tier publications (i.e. Nature, Cell Systems, iScience)

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Xiaoqiang Hou, Ph.D.


Co-founder/Chief Operating Officer


● Deputy Secretary-General of Internet Hospital Association


● 20 years experience in research management, and clinical hospital management

● Research background in tumor and rare diseases, pathogenic mechanisms and vaccines

● Presided over a number of National Key Research Projects

● Ph.D. in Virology, Jilin University

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Haihong Liu, M.D.


Technical Director of Clinical Laboratory


● Ex-Medical Laboratory Specialist of General Hospital of Beijing Military Region

● Genetic Metabolic Disease Laboratory Director of Bayi Children's Hospital

● Specialized in molecular biology and immunology diagnosis


● Evaluation expert of Beijing natural science foundation


● M.D. in preventive medicine, Academy of Military Medical Sciences


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Wei Ye, Ph.D.


VP Scientific Affairs


● Head of Bioinformatics Platform, Bio-Med Big Data Center, Shanghai Institute of Biological Sciences, CAS, lead efforts of building NODE (National Omics Data Encylopedia)

● 10 years experience in multi-omics bioinformatics analysis

● Director of Bioinformatics, Shanghai Tissue Bank Co. Ltd.

● Project Assistant at Roche pRED China


● Ph.D. in Biology, Shanghai Jiaotong University

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Atefeh Kazeroonian, Ph.D.


Computational Modelling Director


● Computational biologist, experienced in mechanistic modelling and omics data integration with a focus on the immune system

● Group leader in computational biology and T cell immunology, Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich


● Ph.D., Computational Biology, Helmholtz Center in Munich in the Fabian Theis lab


● Visiting scholar, University of California, San Francisco


● Published multiple top tier publications (i.e. Nature Immunology, PNAS, Bioinformatics)


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Robin Chan, Ph.D.


VP of Strategic Partnerships


● 10+ years of experience in research and life science industry

● Founding director of Lipidomics Core Laboratory, Columbia University

● Assistant Professor of Pathology and Cell Biology, Lipid Metabolism and Neurodegenerative Diseases, Columbia University

● U.C. Berkeley Skydeck BioChina Fund partner

● PhD, Biochemistry, National University of Singapore, in the Lab of Markus R. Wenk; MBA, Columbia Business School


● Published 35+ top-tier publications (i.e. Nature, Nat Commun., Nat Neurosci., Cell Host Microbe), received research grants from National Institute of Health (NIH) and other non-profit research foundations 

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Chunjian Huang, Ph.D.


VP of Immunology


● 20+ years international experience in immunology-focused research institutes and biotechnology companies (e.g. cancer immunotherapy, autoimmunity, asthma and inflammation)


● Served as Director at Department of Oncology and Immunology, WuXi AppTec. Led R&D progress that enabled the development of new modalities and was involved in multiple successful IND applications

● Served as Principal Investigator at Innovent Biologics. Led team for first-in-class drug target discovery and successfully completed the POC of one FIC target within one year

● PostDoc, Cleveland Clinic (Department of Cancer Biology); Ph.D. in Immunology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; B.Sc. in Biology, Fudan University 

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Wei Ye, Ph.D.


Co-founder/SVP of Technology Operations


● 10+ years experience in bioinformatics research institutes and pharmaceutical companies (focus on NGS, multi-omics data analysis, CADD)


● Served as Director of the Bioinformatics Platform, Shanghai Academy of Biological Sciences, Chinese Academy of Sciences. Led multiple national omics database setup and data analysis programs

● Served at the Roche R&D Center Bioinformatics and worked on several drug discovery projects

Ph.D. in Biology (Bioinformatics), Shanghai Jiaotong University


● Published 20+ SCI papers, including 8 first-authored papers, with 500+ citations

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Glycolysis/gluconeogenesis specialization in microbes is driven by biochemical constraints of flux sensing

Central carbon metabolism is highly conserved across microbial species, but can catalyze very different pathways depending on the organism and their ecological niche. Here, we study the dynamic reorganization of central metabolism after switches between the two major opposing pathway configurations of central carbon metabolism, glycolysis, and gluconeogenesis in Escherichia coli, Pseudomonas aeruginosa, and Pseudomonas putida. We combined growth dynamics and dynamic changes in intracellular metabolite levels with a coarse-grained model that integrates fluxes, regulation, protein synthesis, and growth and uncovered fundamental limitations of the regulatory network: After nutrient shifts, metabolite concentrations collapse to their equilibrium, rendering the cell unable to sense which direction the flux is supposed to flow through the metabolic network. The cell can partially alleviate this by picking a preferred direction of regulation at the expense of increasing lag times in the opposite direction. Moreover, decreasing both lag times simultaneously comes at the cost of reduced growth rate or higher futile cycling between metabolic enzymes. These three trade-offs can explain why microorganisms specialize for either glycolytic or gluconeogenic substrates and can help elucidate the complex growth patterns exhibited by different microbial species.


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contact@alivexbiotech.com


Zeunerstrasse 9, 8037 Zurich


  

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