Shirley Wen
Founder/CEO
● 10+ years of interdisciplinary product and managing experience, transforming traditional businesses with frontier digital technologies
● Ex hegdefund portfolio manager, focused on healthcare, TMT, and consumer
● MSc Accounting & Finance, The London School of Economics
Douglas McCloskey, Ph.D.
Co-founder/Chief Scientist
● Systems biologist experienced in developing automated Big Omics Data generation and analysis workflows
● Group leader, Center for Biosustainability (CfB) at the Technical University of Denmark (DTU)
● Ph.D., Bioengineering, University of California, San Diego in the Bernhard Ø. Palsson lab
● Recipient of the Siebel Scholar – awarded annually for academic excellence and demonstrated leadership to 93 top students from the world‘s leading graduate schools
● Publication H-index of 21
Dimitris Christodoulou, Ph.D.
Co-founder/Chief Strategy Officer
● Strategist & computational biologist with experience in data analytics, multi-omics integration & simulation
● Ex-Senior Consultant at Deloitte Consulting (Zurich), led the design and implementation of business and technology strategies as well as data solutions for global MNCs
● Visiting Scholar in Systems Biology, Harvard Medical School
● Ph.D. & Post-Doc, Computational Biology, ETH Zurich
● Published multiple top tier publications (i.e. Nature, Cell Systems, iScience)
Xiaoqiang Hou, Ph.D.
Co-founder/Chief Operating Officer
● Deputy Secretary-General of Internet Hospital Association
● 20 years experience in research management, and clinical hospital management
● Research background in tumor and rare diseases, pathogenic mechanisms and vaccines
● Presided over a number of National Key Research Projects
● Ph.D. in Virology, Jilin University
Haihong Liu, M.D.
Technical Director of Clinical Laboratory
● Ex-Medical Laboratory Specialist of General Hospital of Beijing Military Region
● Genetic Metabolic Disease Laboratory Director of Bayi Children's Hospital
● Specialized in molecular biology and immunology diagnosis
● Evaluation expert of Beijing natural science foundation
● M.D. in preventive medicine, Academy of Military Medical Sciences
Wei Ye, Ph.D.
VP Scientific Affairs
● Head of Bioinformatics Platform, Bio-Med Big Data Center, Shanghai Institute of Biological Sciences, CAS, lead efforts of building NODE (National Omics Data Encylopedia)
● 10 years experience in multi-omics bioinformatics analysis
● Director of Bioinformatics, Shanghai Tissue Bank Co. Ltd.
● Project Assistant at Roche pRED China
● Ph.D. in Biology, Shanghai Jiaotong University
Atefeh Kazeroonian, Ph.D.
Computational Modelling Director
● Computational biologist, experienced in mechanistic modelling and omics data integration with a focus on the immune system
● Group leader in computational biology and T cell immunology, Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich
● Ph.D., Computational Biology, Helmholtz Center in Munich in the Fabian Theis lab
● Visiting scholar, University of California, San Francisco
● Published multiple top tier publications (i.e. Nature Immunology, PNAS, Bioinformatics)
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Robin Chan, Ph.D.
VP of Strategic Partnerships
● 10+ years of experience in research and life science industry
● Founding director of Lipidomics Core Laboratory, Columbia University
● Assistant Professor of Pathology and Cell Biology, Lipid Metabolism and Neurodegenerative Diseases, Columbia University
● U.C. Berkeley Skydeck BioChina Fund partner
● PhD, Biochemistry, National University of Singapore, in the Lab of Markus R. Wenk; MBA, Columbia Business School
● Published 35+ top-tier publications (i.e. Nature, Nat Commun., Nat Neurosci., Cell Host Microbe), received research grants from National Institute of Health (NIH) and other non-profit research foundations
Chunjian Huang, Ph.D.
VP of Immunology
● 20+ years international experience in immunology-focused research institutes and biotechnology companies (e.g. cancer immunotherapy, autoimmunity, asthma and inflammation)
● Served as Director at Department of Oncology and Immunology, WuXi AppTec. Led R&D progress that enabled the development of new modalities and was involved in multiple successful IND applications
● Served as Principal Investigator at Innovent Biologics. Led team for first-in-class drug target discovery and successfully completed the POC of one FIC target within one year
● PostDoc, Cleveland Clinic (Department of Cancer Biology); Ph.D. in Immunology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; B.Sc. in Biology, Fudan University
Wei Ye, Ph.D.
Co-founder/SVP of Technology Operations
● 10+ years experience in bioinformatics research institutes and pharmaceutical companies (focus on NGS, multi-omics data analysis, CADD)
● Served as Director of the Bioinformatics Platform, Shanghai Academy of Biological Sciences, Chinese Academy of Sciences. Led multiple national omics database setup and data analysis programs
● Served at the Roche R&D Center Bioinformatics and worked on several drug discovery projects
● Ph.D. in Biology (Bioinformatics), Shanghai Jiaotong University
● Published 20+ SCI papers, including 8 first-authored papers, with 500+ citations
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News
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Precision diagnostic approach to predict 5-year risk for microvascular complications in type 1 diabetes
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Cooperative catalysis by a single-atom enzyme-metal complex
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A common framework of monocyte-derived macrophage activation
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Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice
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A Comprehensive Evaluation of Metabolomics Data Preprocessing Methods for Deep Learning
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α-Synuclein-containing erythrocytic extracellular vesicles: essential contributors to hyperactivation of monocytes in Parkinson's disease
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Glycolysis/gluconeogenesis specialization in microbes is driven by biochemical constraints of flux sensing
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Astrocytic VEGFA: An essential mediator in blood-brain-barrier disruption in Parkinson's disease
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Corrigendum: Multi-Omics Analysis of Fatty Alcohol Production in Engineered Yeasts Saccharomyces cerevisiae and Yarrowia lipolytica
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SmartPeak Automates Targeted and Quantitative Metabolomics Data Processing
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A universal trade-off between growth & lag in fluctuating environments
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Phospholipase D1 Ablation Disrupts Mouse Longitudinal Hippocampal Axis Organization and Functioning
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Cell Mechanics Based Computational Classification of Red Blood Cells Via Machine Intelligence Applied to Morpho-Rheological Markers.
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Reserve Flux Capacity in the Pentose Phosphate Pathway by NADPH Binding Is Conserved across Kingdoms
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Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment
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Laboratory evolution reveals a two-dimensional rate-yield tradeoff in microbial metabolism
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A White-Box Machine Learning Approach for Revealing Antibiotic Mechanisms of Action
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E-cadherin expression on multiple myeloma cells activates tumor-promoting properties in plasmacytoid DCs
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Evolution of gene knockout strains of E. coli reveal regulatory architectures governed by metabolism
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Growth Adaptation of gnd and sdhCB Escherichia coli Deletion Strains Diverges From a Similar Initial Perturbation of the Transcriptome
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Reserve Flux Capacity in the Pentose Phosphate Pathway Enables Escherichia coli's Rapid Response to Oxidative Stress
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Cholesterol negatively regulates IL-9–producing CD8+ T cell differentiation and antitumor activity
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Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures
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Antibiotic-induced changes to the host metabolic environment inhibit drug efficacy and alter immune function
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Genome-Scale Architecture of Small Molecule Regulatory Networks and the Fundamental Trade-Off between Regulation and Enzymatic Activity
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Enlightening discriminative network functional modules behind Principal Component Analysis separation in differential-omic science studies
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Arf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism
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TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis
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Characterizing strain variation in engineered E. coli using a multi-omics-based workflow
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Pseudo-transition Analysis Identifies the Key Regulators of Dynamic Metabolic Adaptations from Steady-State Data
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Profiling the Essential Nature of Lipid Metabolism in Asexual Blood and Gametocyte Stages of Plasmodium falciparum
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MUC18 Differentially Regulates Pro-Inflammatory and Anti-Viral Responses in Human Airway Epithelial Cells
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Identification of interactions in fractional-order systems with high dimensions
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Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells
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AMPD2 regulates GTP synthesis and is mutated in a potentially treatable neurodegenerative brainstem disorder
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Knockout punch: cardiolipin oxidation in trauma
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Bifurcations of emergent bursting in a neuronal network
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Approximating the double-cut-and-join distance between unsigned genomics
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Adaptively Locating Unknown Steady States: Formalism And Basin Of Attraction
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Novel function of perforin in negatively regulating CD4+ T cell activation by affecting calcium signaling
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Isoform-Specific Inhibition of RORα-Mediated Transcriptional Activation by Human FOXP3
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eBioMedicine | Precision diagnostic appro...
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Nat. Commun. | Cooperative catalysis by a...
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Sci. Immunol. | A common framework of mon...
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Transl. Psychiatry | Effects of APOE4 all...
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Metabolites | A Comprehensive Evaluation ...
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J. Neuroinflammation | α-Synuclein-contai...
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Mol. Syst. Biol | Glycolysis/gluconeogene...
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GLIA | Astrocytic VEGFA: An essential med...
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Front. Genet. | Corrigendum: Multi-Omics ...
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Anal. Chem. | SmartPeak Automates Targete...
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Nature | A universal trade-off between gr...
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Cell Rep. | Phospholipase D1 Ablation Dis...
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IEEE/ACM TCBB | Cell Mechanics Based Comp...
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iScience | Reserve Flux Capacity in the P...
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Cell Metab. | Cholesterol Induces CD8+ T ...
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PLoS Comput. Biol. | Laboratory evolution...
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Cell | A White-Box Machine Learning Appro...
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J. Clin. Investig. | E-cadherin expressio...
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Nat. Commun. | Evolution of gene knockout...
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Front. Microbiol. | Growth Adaptation of ...
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Cell Syst. | Reserve Flux Capacity in the...
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