Shirley Wen
Founder/CEO
● 10+ years of interdisciplinary product and managing experience, transforming traditional businesses with frontier digital technologies
● Ex hegdefund portfolio manager, focused on healthcare, TMT, and consumer
● MSc Accounting & Finance, The London School of Economics
Douglas McCloskey, Ph.D.
Co-founder/Chief Scientist
● Systems biologist experienced in developing automated Big Omics Data generation and analysis workflows
● Group leader, Center for Biosustainability (CfB) at the Technical University of Denmark (DTU)
● Ph.D., Bioengineering, University of California, San Diego in the Bernhard Ø. Palsson lab
● Recipient of the Siebel Scholar – awarded annually for academic excellence and demonstrated leadership to 93 top students from the world‘s leading graduate schools
● Publication H-index of 21
Dimitris Christodoulou, Ph.D.
Co-founder/Chief Strategy Officer
● Strategist & computational biologist with experience in data analytics, multi-omics integration & simulation
● Ex-Senior Consultant at Deloitte Consulting (Zurich), led the design and implementation of business and technology strategies as well as data solutions for global MNCs
● Visiting Scholar in Systems Biology, Harvard Medical School
● Ph.D. & Post-Doc, Computational Biology, ETH Zurich
● Published multiple top tier publications (i.e. Nature, Cell Systems, iScience)
Xiaoqiang Hou, Ph.D.
Co-founder/Chief Operating Officer
● Deputy Secretary-General of Internet Hospital Association
● 20 years experience in research management, and clinical hospital management
● Research background in tumor and rare diseases, pathogenic mechanisms and vaccines
● Presided over a number of National Key Research Projects
● Ph.D. in Virology, Jilin University
Haihong Liu, M.D.
Technical Director of Clinical Laboratory
● Ex-Medical Laboratory Specialist of General Hospital of Beijing Military Region
● Genetic Metabolic Disease Laboratory Director of Bayi Children's Hospital
● Specialized in molecular biology and immunology diagnosis
● Evaluation expert of Beijing natural science foundation
● M.D. in preventive medicine, Academy of Military Medical Sciences
Wei Ye, Ph.D.
VP Scientific Affairs
● Head of Bioinformatics Platform, Bio-Med Big Data Center, Shanghai Institute of Biological Sciences, CAS, lead efforts of building NODE (National Omics Data Encylopedia)
● 10 years experience in multi-omics bioinformatics analysis
● Director of Bioinformatics, Shanghai Tissue Bank Co. Ltd.
● Project Assistant at Roche pRED China
● Ph.D. in Biology, Shanghai Jiaotong University
Atefeh Kazeroonian, Ph.D.
Computational Modelling Director
● Computational biologist, experienced in mechanistic modelling and omics data integration with a focus on the immune system
● Group leader in computational biology and T cell immunology, Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich
● Ph.D., Computational Biology, Helmholtz Center in Munich in the Fabian Theis lab
● Visiting scholar, University of California, San Francisco
● Published multiple top tier publications (i.e. Nature Immunology, PNAS, Bioinformatics)
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Robin Chan, Ph.D.
Chief Scientist, Multi-omics
● 15+ years of life science industry experience, with roles in research and business development
● Assistant Professor in the Department of Pathology and Cell Biology, Columbia University Medical Center, specializing in lipid metabolism and neurodegenerative diseases, received research grants from the National Institute of Health (NIH) and other non-profit research foundations
● Founding director of Lipidomics Core Laboratory, Columbia University Medical Center, led numerous collaborative projects in a wide variety of fields including neurodegenerative diseases, infectious diseases, and biomarker discovery
● Business development and strategic partnership experience with products related to cancer diagnostics, cell therapy, and systems biology analytical services
● PhD, Biochemistry, National University of Singapore, in the Lab of Markus R. Wenk; MBA, Columbia Business School
● Published 40+ papers, including multiple top-tier publications (i.e. Nature, Nat Commun., Nat Neurosci., Cell Host Microbe)
Ge Yan, Ph.D.
Senior Bioinformatics Scientist
● 10+ years of experience in bioinformatics research and analysis with a focus on pathogenesis discovery of immune-related diseases, ML-based multi-omics data analysis and pipeline construction
● Senior Bioinformatics Scientist, Institute for Immunology, Dresden, Germany, led multiple projects in immunoinformatics and systems biology
● Postdoc, Bioinformatics, BIOTEC Institute, Dresden, Germany
● PhD, Bioinformatics, China Agriculture University and Beijing Institute of Genomics, Chinese Academy of Sciences, China
● Published 10+ top-tier publications (i.e. Science Immunology, Nature Methods)
Wei Ye, Ph.D.
Co-founder/SVP of Technology Operations
● 10+ years experience in bioinformatics research institutes and pharmaceutical companies (focus on NGS, multi-omics data analysis, CADD)
● Served as Director of the Bioinformatics Platform, Shanghai Academy of Biological Sciences, Chinese Academy of Sciences. Led multiple national omics database setup and data analysis programs
● Served at the Roche R&D Center Bioinformatics and worked on several drug discovery projects
● Ph.D. in Biology (Bioinformatics), Shanghai Jiaotong University
● Published 20+ SCI papers, including 8 first-authored papers, with 500+ citations
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News
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Precision diagnostic approach to predict 5-year risk for microvascular complications in type 1 diabetes
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Cooperative catalysis by a single-atom enzyme-metal complex
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A common framework of monocyte-derived macrophage activation
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Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice
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A Comprehensive Evaluation of Metabolomics Data Preprocessing Methods for Deep Learning
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α-Synuclein-containing erythrocytic extracellular vesicles: essential contributors to hyperactivation of monocytes in Parkinson's disease
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Glycolysis/gluconeogenesis specialization in microbes is driven by biochemical constraints of flux sensing
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Astrocytic VEGFA: An essential mediator in blood-brain-barrier disruption in Parkinson's disease
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Corrigendum: Multi-Omics Analysis of Fatty Alcohol Production in Engineered Yeasts Saccharomyces cerevisiae and Yarrowia lipolytica
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SmartPeak Automates Targeted and Quantitative Metabolomics Data Processing
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A universal trade-off between growth & lag in fluctuating environments
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Phospholipase D1 Ablation Disrupts Mouse Longitudinal Hippocampal Axis Organization and Functioning
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Cell Mechanics Based Computational Classification of Red Blood Cells Via Machine Intelligence Applied to Morpho-Rheological Markers.
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Reserve Flux Capacity in the Pentose Phosphate Pathway by NADPH Binding Is Conserved across Kingdoms
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Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment
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Laboratory evolution reveals a two-dimensional rate-yield tradeoff in microbial metabolism
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A White-Box Machine Learning Approach for Revealing Antibiotic Mechanisms of Action
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E-cadherin expression on multiple myeloma cells activates tumor-promoting properties in plasmacytoid DCs
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Evolution of gene knockout strains of E. coli reveal regulatory architectures governed by metabolism
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Growth Adaptation of gnd and sdhCB Escherichia coli Deletion Strains Diverges From a Similar Initial Perturbation of the Transcriptome
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Reserve Flux Capacity in the Pentose Phosphate Pathway Enables Escherichia coli's Rapid Response to Oxidative Stress
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Cholesterol negatively regulates IL-9–producing CD8+ T cell differentiation and antitumor activity
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Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures
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Antibiotic-induced changes to the host metabolic environment inhibit drug efficacy and alter immune function
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Genome-Scale Architecture of Small Molecule Regulatory Networks and the Fundamental Trade-Off between Regulation and Enzymatic Activity
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Enlightening discriminative network functional modules behind Principal Component Analysis separation in differential-omic science studies
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Arf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism
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TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis
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Characterizing strain variation in engineered E. coli using a multi-omics-based workflow
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Pseudo-transition Analysis Identifies the Key Regulators of Dynamic Metabolic Adaptations from Steady-State Data
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Profiling the Essential Nature of Lipid Metabolism in Asexual Blood and Gametocyte Stages of Plasmodium falciparum
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MUC18 Differentially Regulates Pro-Inflammatory and Anti-Viral Responses in Human Airway Epithelial Cells
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Identification of interactions in fractional-order systems with high dimensions
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Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells
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AMPD2 regulates GTP synthesis and is mutated in a potentially treatable neurodegenerative brainstem disorder
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Knockout punch: cardiolipin oxidation in trauma
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Bifurcations of emergent bursting in a neuronal network
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Approximating the double-cut-and-join distance between unsigned genomics
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Adaptively Locating Unknown Steady States: Formalism And Basin Of Attraction
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Novel function of perforin in negatively regulating CD4+ T cell activation by affecting calcium signaling
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Isoform-Specific Inhibition of RORα-Mediated Transcriptional Activation by Human FOXP3
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eBioMedicine | Precision diagnostic appro...
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Nat. Commun. | Cooperative catalysis by a...
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Sci. Immunol. | A common framework of mon...
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Transl. Psychiatry | Effects of APOE4 all...
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Metabolites | A Comprehensive Evaluation ...
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J. Neuroinflammation | α-Synuclein-contai...
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Mol. Syst. Biol | Glycolysis/gluconeogene...
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GLIA | Astrocytic VEGFA: An essential med...
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Front. Genet. | Corrigendum: Multi-Omics ...
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Anal. Chem. | SmartPeak Automates Targete...
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Nature | A universal trade-off between gr...
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Cell Rep. | Phospholipase D1 Ablation Dis...
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IEEE/ACM TCBB | Cell Mechanics Based Comp...
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iScience | Reserve Flux Capacity in the P...
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Cell Metab. | Cholesterol Induces CD8+ T ...
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PLoS Comput. Biol. | Laboratory evolution...
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Cell | A White-Box Machine Learning Appro...
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J. Clin. Investig. | E-cadherin expressio...
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Nat. Commun. | Evolution of gene knockout...
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Front. Microbiol. | Growth Adaptation of ...
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Cell Syst. | Reserve Flux Capacity in the...
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